Purpose: The present study aimed to compare Musculoskeletal Discomforts (MSDs) among six different common postures while working with laptop in female students of University of Tehran, Tehran City, Iran.
Methods: This was a crossover trial study. Eighteen female students voluntarily and purposefully participated in all stages of the study. The study participants were randomly assigned into groups to work for 10 minutes on different postures for laptop use during six continuous nights. MSDs was measured each night after 10 minutes of laptop use. For this purpose, Van der Grinten and Smith (1992) method was applied. The obtained data were analyzed by repeated measures one-way ANOVA at a significance level of P≤0.05, in SPSS.
Results: The obtained results suggested a significant difference among six working postures in MSDs (P=0.005). The results of Bonferroni post hoc analysis revealed that the highest level of MSDs was observed in a cross-legged sitting position on the floor. While, the lowest level of MSDs was found in the sitting on a chair posture. In addition, the study participants who used a desk in order to increase the height of the laptop, reported less levels of MSDs than laptop use in the cross-legged position on the floor (P=0.039) or sitting on the bed (P=0.011).
Conclusion: According to this study, in order to minimize MSDs during working with laptop, it is recommended to use desk and chairs instead of sitting cross-legged on the floor or bed.

Purpose: One of the biggest factors reportedly interfering with the lives of individuals who suffer from multiple sclerosis (MS) is fatigue. Prior research has demonstrated that combined training may benefit patients with MS. However, it has not been studied how combined exercise can lessen fatigue in people with MS. This systematic review and meta-analysis summarizes the results of studies that examine the effects of combined training on fatigue in individuals with MS.
Methods: We investigated randomized controlled studies (RCTs) that examined how combination training affected fatigue and were published from the start of the research until May 2024. The Wiley online library, PubMed, Medline, PEDro, ScienceDirect, and Frontiers were among the electronic databases that were searched. PEDro and McMaster’s measures were used to assess the quality of included research. 
Results: The study’s requirements were satisfied by six RCTs with 279 participants. Using a random effect model of meta-analysis, the weighted mean differences of fatigue were 1.81 (95% CI, 2.83%, 0.79%) with P=0.002. Accordingly, exercise training is useful in lowering fatigue in individuals with MS since all included RCTs revealed significant differences between the subjects assigned to the combined exercise group and the control group. 
Conclusion: Combined training can be a useful strategy for helping individuals with MS manage their weariness.