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Eslami R. Research Landscape of Exercise-related Extracellular Vesicles: A Bibliometric Analysis (2010–2024). PTJ 2026; 16 (2) :115-126
URL: http://ptj.uswr.ac.ir/article-1-802-en.html

Purpose: Extracellular vesicles (EVs) are key mediators of interorgan communication during exercise, with growing research interest in their role in exercise physiology and health. This study aimed to map the research landscape of exercise-related EVs from 2010 to 2024 using bibliometric analysis.
Methods: We analyzed 398 publications (252 articles and 146 reviews) from the Web of Science Core Collection (WoSCC), employing the Bibliometrix R package software, version 4.4.1, VOSviewer software, version 1.6.20, and Microsoft Excel to evaluate publication trends, key contributors, and research foci.
Results: The field exhibits a robust annual growth rate of 30.38%, with a peak of 85 publications and 2411 citations in 2023. China and the United States lead publication output, together accounting for 36% of total publications, with key institutions, including the University of Pittsburgh and Harvard University. Core journals, such as Frontiers in Physiology and International Journal of Molecular Sciences, dominate the field. Keyword analysis highlights “ EVs,” “exosomes,” “exercise,” and “skeletal muscle” as central themes, alongside emerging topics, such as micro ribonucleic acids (microRNAs), oxidative stress, and insulin resistance.
Conclusion: These findings underscore the increasing recognition of EVs as critical mediators of exercise-induced interorgan crosstalk and their potential as biomarkers for health and disease, providing a foundation for future interdisciplinary research in exercise physiology and EV biology.