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Fasihi L, Shahrbanian S, Jahangiri M. Effects of Combined Training on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials. PTJ 2025; 15 (1) :1-14
URL: http://ptj.uswr.ac.ir/article-1-665-en.html

Purpose: One of the biggest factors reportedly interfering with the lives of individuals who suffer from multiple sclerosis (MS) is fatigue. Prior research has demonstrated that combined training may benefit patients with MS. However, it has not been studied how combined exercise can lessen fatigue in people with MS. This systematic review and meta-analysis summarizes the results of studies that examine the effects of combined training on fatigue in individuals with MS.
Methods: We investigated randomized controlled studies (RCTs) that examined how combination training affected fatigue and were published from the start of the research until May 2024. The Wiley online library, PubMed, Medline, PEDro, ScienceDirect, and Frontiers were among the electronic databases that were searched. PEDro and McMaster’s measures were used to assess the quality of included research. 
Results: The study’s requirements were satisfied by six RCTs with 279 participants. Using a random effect model of meta-analysis, the weighted mean differences of fatigue were 1.81 (95% CI, 2.83%, 0.79%) with P=0.002. Accordingly, exercise training is useful in lowering fatigue in individuals with MS since all included RCTs revealed significant differences between the subjects assigned to the combined exercise group and the control group. 
Conclusion: Combined training can be a useful strategy for helping individuals with MS manage their weariness.