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1- Gabriel Manek Atambua General Regional Hospital, Belu, East Nusa Tenggara, Indonesia.
2- Bunda Citra Harapan Hospital, Bekasi, West Java, Indonesia.
3- Carolus Borromeus Hospital, Kupang, East Nusa Tenggara, Indonesia.
4- Cideres General Regional Hospital, Majalengka, West Java, Indonesia.
2- Bunda Citra Harapan Hospital, Bekasi, West Java, Indonesia.
3- Carolus Borromeus Hospital, Kupang, East Nusa Tenggara, Indonesia.
4- Cideres General Regional Hospital, Majalengka, West Java, Indonesia.
Abstract: (23 Views)
Purpose: The objective of this research was to assess how hydrotherapy influences range of motion (ROM) and pain among hemophilia patients.
Methods: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelinesA thorough literature search was carried out in October 2024, across several databases, including PubMed, ProQuest, ScienceDirect, and Cochrane. The Cochrane Risk of Bias (RoB) 2 tool and the Risk Of Bias In Non-randomized Studies – of Interventions (ROBINS-I V2) were applied for study quality assessment, while Review Manager (RevMan) 5.4 was utilized for meta-analysis.
Results: In total, three studies were analyzed, and the methodological appraisal showed that two had low risk and one had moderate risk of bias. Significant improvements in knee extension ROM (SMD = 1.17, 95% CI [0.15, 2.18], p = 0.02) and decreases in pain (SMD = -1.46, 95% CI [-2.00, -0.91], p = < 0.0001) were observed in the hydrotherapy group versus controls. However, knee flexion ROM improvement was not statistically significant (SMD = 2.17, 95% CI [-0.42, 4.77], p = 0.10).
Conclusion: Hydrotherapy demonstrates potential benefits in improving knee ROM and pain in hemophilia, particularly in knee extension. However, variability across studies limits the certainty of these findings. Further large-scale randomized controlled trials (RCT) with standardized intervention protocols are required to clarify long-term outcomes and encourage widespread clinical application.
Methods: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelinesA thorough literature search was carried out in October 2024, across several databases, including PubMed, ProQuest, ScienceDirect, and Cochrane. The Cochrane Risk of Bias (RoB) 2 tool and the Risk Of Bias In Non-randomized Studies – of Interventions (ROBINS-I V2) were applied for study quality assessment, while Review Manager (RevMan) 5.4 was utilized for meta-analysis.
Results: In total, three studies were analyzed, and the methodological appraisal showed that two had low risk and one had moderate risk of bias. Significant improvements in knee extension ROM (SMD = 1.17, 95% CI [0.15, 2.18], p = 0.02) and decreases in pain (SMD = -1.46, 95% CI [-2.00, -0.91], p = < 0.0001) were observed in the hydrotherapy group versus controls. However, knee flexion ROM improvement was not statistically significant (SMD = 2.17, 95% CI [-0.42, 4.77], p = 0.10).
Conclusion: Hydrotherapy demonstrates potential benefits in improving knee ROM and pain in hemophilia, particularly in knee extension. However, variability across studies limits the certainty of these findings. Further large-scale randomized controlled trials (RCT) with standardized intervention protocols are required to clarify long-term outcomes and encourage widespread clinical application.
Type of Study: Systematic Review |
Subject:
Physical Therapy
Received: 2025/09/13 | Accepted: 2026/01/6
Received: 2025/09/13 | Accepted: 2026/01/6
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