en فیزیوتراپی Physical Therapy مرور سیستماتیک/ آنالیز متا Systematic Review <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><b><span lang="EN">Purpose: </span></b><span lang="EN">The objective of this research was to assess how hydrotherapy influences range of motion (ROM) and pain among hemophilia patients. </span><br> <b><span lang="EN">Methods: </span></b><span lang="EN">This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelinesA thorough literature search was carried out in October 2024, across several databases, including PubMed, ProQuest, ScienceDirect, and Cochrane. The Cochrane Risk of Bias (RoB) 2 tool and the Risk Of Bias In Non-randomized Studies &ndash; of Interventions (ROBINS-I V2) were applied for study quality assessment, while Review Manager (RevMan) 5.4 was utilized for meta-analysis. </span><br> <b><span lang="EN">Results: </span></b><span lang="EN">In total, three studies were analyzed, and the methodological appraisal showed that two had low risk and one had moderate risk of bias. Significant improvements in knee extension ROM (SMD = 1.17, 95% CI [0.15, 2.18], p = 0.02) and decreases in pain (SMD = -1.46, 95% CI [-2.00, -0.91], p = < 0.0001) were observed in the hydrotherapy group versus controls. However, knee flexion ROM improvement was not statistically significant (SMD = 2.17, 95% CI [-0.42, 4.77], p = 0.10). </span><br> <b><span lang="EN">Conclusion: </span></b><span lang="EN">Hydrotherapy demonstrates potential benefits in improving knee ROM and pain in hemophilia,</span> <span lang="EN">particularly in knee extension. However, variability across studies limits the certainty of these findings. Further large-scale randomized controlled trials (RCT) with standardized intervention protocols are required to clarify long-term outcomes and encourage widespread clinical application.</span></span></span></span></div> Hydrotherapy, Hemophilia, Rehabilitation, Range of motion, Pain 0 0 http://ptj.uswr.ac.ir/browse.php?a_code=A-10-758-1&slc_lang=en&sid=1 Kevin Axel Chandra Kevin19axel@gmail.com 0009-0007-1812-4000 Yes Gabriel Manek Atambua General Regional Hospital, Belu, East Nusa Tenggara, Indonesia. Astrid Priscilla Amanda astridpriscilla91@gmail.com 0000-0001-5629-5715 No Bunda Citra Harapan Hospital, Bekasi, West Java, Indonesia. Jenifer Nathania jen.nath37@gmail.com 0009-0008-6300-3387 No Carolus Borromeus Hospital, Kupang, East Nusa Tenggara, Indonesia. Maximillian Aritonang maxarf9t@gmail.com 0009-0009-0590-5435 No Cideres General Regional Hospital, Majalengka, West Java, Indonesia.